ABSTRACT
The article provided the information about the results of clinical-morphological analysis of the practical observation with pulmonary aspergillosis associated with COVID-19 and undiagnosed when the patient was alive. The pulmonary aspergillosis associated with COVID-19 is one of the widespread complications. However, in numerous cases, the pulmonary aspergillosis associated with COVID-19 is not diagnosed due to its unclear signs and lack of information about it. An infiltrate with signs of destruction was noted during X-ray examination of the lower part of the right lung of the observed patient. It was evaluated as destructive pneumonia associated with bacterial infection. However, despite the patient had type II diabetes, no additional examination methods were applied to exclude aspergillosis. Disruption of the protective properties of the bronchial epithelium and the effect of oseltamivir type drugs may also contribute to the entry of aspergillus fungi into the lung tissue. According to the authors, during the development of diagnosis, treatment and prevention strategy of COVID-19in the patients with pulmonary aspergillosis it is important to study the interaction of these diseases.Copyright © 2022 Authors. All rights reserved.
ABSTRACT
The paper presents the pathomorphological changes in the kidneys of patients, who died from severe COVID-19, and analyzed the literature to substantiate the possible pathophysiological patterns of their development. The material for the study was pieces of kidneys taken during autopsy of 16 deceased with severe COVID-19 without a history of kidney disease. Pathological changes in COVID-19-related acute kidney injury were manifested by non-specific changes in the glomeruli, the presence of blood clots in the blood vessels, dystrophy, necrosis, and desquamation of the epithelial cells of the nephron tubules. Pathological changes in the kidney structures resulted from both the direct nephrotoxic effect of the SARS-CoV-2 virus and the indirect effect of systemic hypoxia, hypercoagulation, hyperventilation. Moreover, cross-organ damage covering the lung-kidney and heart-kidney axes was not excluded. Systemic endothelial dysfunction presumably plays one of the key roles in the development of acute kidney injury. Thus, the present study reveals the potential pathogenetic links of COVID-19-related acute kidney injury.